the lancet website home page
gold confetti — copyright: ktsdesign/science photo library
cannabidiol molecular structure — copyright: ramon andrade 3dciencia/science photo library
people waiting in an emergency room — copyright: albert gonzález farran, unamid / flickr images
richard horton — copyright: tim fulda 2013
listen to the lancet’s editor-in-chief, dr richard horton, discuss his global health highlights from 2017, as well as his hopes for global health and upcoming projects for the journal in 2018.
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a 78-year-old man was admitted to hospital for treatment of stage iiia squamous cell carcinoma of the lung. he reported a 4 week history of pain, erythema, and oedema in the left middle finger tip, which impaired his sleep and hand function.
the lancet journals
the lancet neurology
published: november 6, 2017
traumatic brain injury (tbi) is a public health challenge of vast, but insufficiently recognised, proportions. tbi is the leading cause of mortality in young adults and a major cause of death and disability across all ages in all countries. in high-income countries, the number of elderly people with tbi is increasing, mainly due to falls, while in low-income and middle-income countries, the burden of tbi from road traffic incidents is increasing.
the lancet oncology
published: october 31, 2017
enactment of the cancer moonshot within the 21st century cures act in the usa arrived at a propitious moment in the advancement of knowledge, providing nearly us$2 billion of funding for cancer research and precision medicine. in 2016, the blue ribbon panel (brp) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment. those recommendations provided a high-level view of how to accelerate the conversion of new scientific discoveries into effective treatments and prevention for cancer.
published: october 19, 2017
for decades, pollution and its harmful effects on people’s health, the environment, and the planet have been neglected both by governments and the international development agenda. yet, pollution is the largest environmental cause of disease and death in the world today, responsible for an estimated 9 million premature deaths.
alleviating the access abyss in palliative care and pain relief—an imperative of universal health coverage: the lancet commission report
published: october 13, 2017
the lack of global access to pain relief and palliative care throughout the life cycle constitutes a global crisis, and action to close this divide between rich and poor is a moral, health, and ethical imperative. the need for palliative care and pain relief has been largely ignored. yet, palliative care and pain relief are essential elements of universal health coverage (uhc).
published: october 4, 2017
the past decade has seen huge advances in the field of stem cell therapy and regenerative medicine and there is a great deal of excitement about the potential promise of these treatments. to date, however, clinical successes have mostly been achieved in small cohorts of patients, and if these therapies are to deliver substantial benefits in routine clinical practice, many challenges will need to be overcome.
the lancet psychiatry
published: september 23, 2017
psychiatry is on the cusp of major changes. it is time to look at where the specialty has been, where it is now, and to try to imagine its future. what will psychiatrists do, and how will this be delivered and financed? how will psychiatry’s relationship with society change? how must mental health laws adapt? can psychiatry go digital? and how will psychiatrists of the future be trained?
the path to longer and healthier lives for all africans by 2030: the lancet commission on the future of health in sub-saharan africa
published: september 13, 2017
africans can be proud of many successes in health such as longer life expectancy, reduced maternal and child mortality, and greater control of hiv and malaria epidemics. however sub-saharan africa faces the well known challenges of conflict, urban and rural exclusion, environmental degradation, and brain drain.
published: september 11, 2017
progress in reducing hospital admissions and mortality in people with asthma have stalled in the past 10 years. this lancet commission examines where we are in the understanding of this heterogeneous syndrome and where we need to go to kickstart a new era of examining, monitoring, treating, and ultimately preventing airways diseases. the commissioners recommend to deconstruct airway disease into component parts before planning treatment with a focus on traits that are identifiable and treatable. this approach will require a complete change in how we think about airways diseases with the goal of achieving real precision treatment with better patient outcomes. in addition, primary prevention and disease-modifying interventions need to become a more important ambition. it is unacceptable that people still die from asthma attacks in 2017.
the lancet gastroenterology & hepatology
published: november 8, 2017
in 2016, who adopted a strategy for the elimination of viral hepatitis by 2030. sub-saharan africa carries a substantial portion of the global burden of viral hepatitis, particularly chronic hepatitis b and hepatitis c. countries in the region face unique challenges, with the development of elimination strategies often hindered by a lack of good quality data.
the lancet neurology
published: september 12, 2017
traumatic brain injury (tbi) is a major cause of death and disability, yet clinical management options are not adequate to deal with the range of consequences. in the first of four series papers in the lancet neurology, nino stocchetti and colleagues highlight the heterogeneity of outcomes and consider ways forward for targeted management of severe tbi in the intensive care unit. next, marc maegele and colleagues review current understanding of coagulopathy and haemorrhagic progression after tbi, focusing on advances in mechanisms, diagnosis, and management. geert meyfroidt and colleagues provide an overview of paroxysmal sympathetic hyperactivity, a consequence of acute brain injury, and discuss the promise of improved characterisation and implications for management. and in the final series paper, lindsay wilson and colleagues consider the growing body of evidence that tbi should be viewed as a chronic and evolving health condition with lifelong consequences for many patients.
published: september 7, 2017
paediatric surgery is possibly the most challenging subspecialty in which to conduct research, and yet current work is pushing the boundaries of biomedical science in many ways. this two-part series contains review papers on paediatric urological and gastrointestinal surgery, two subspecialties selected because they encompass some of the most common paediatric surgical conditions and highlight the exciting research underway in this specialty despite the challenges.
published: august 31, 2017
the global burden of diseases investigators reported that 3·2 million people died worldwide from copd in 2015, an increase of 11·6% compared with 1990. with risk factors such as smoking and household air pollution prevalent in many countries, there continues to be a large burden of disease globally. but not all copd disease is the same. researchers are increasingly interested in the tailoring of treatment to specific patient groups to improve outcome by deciphering different patient groups who might respond variably to treatments. patient endotyping, where patients are separated by their treatment response or disease mechanism is an area of current interest and is discussed in this series. biological markers, such as blood eosinophils, are the focus of another paper, while the final paper focuses on palliative care and refractory breathlessness, a particularly troublesome symptom for patients. this series provides the latest concepts with regards to the biology of disease and mechanistic pathways involved in disease development, with the aim to eventually help guide treatment and management of the patient.
published: august 17, 2017
in the 40 years since sept 16, 1977, when andreas grüntzig did the first non-operative coronary angiography, percutaneous coronary interventions have become a very common procedure in medicine. the development of coronary stents, of imaging techniques to better visualise the lesions and repairs and the development of new adjunctive antithrombotic agents and regimens are very active areas of research. this lancet series summarises in accessible form the history, current situation, and anticipated developments in the field of percutaneous coronary interventions.
the lancet infectious diseases
published: july 31, 2017
fungal infections are neglected by social and political communities. however, they affect more than a billion people, resulting in approximately 11·5 million life-threatening infections and more than 1·5 million deaths annually. there have been enormous advances in fungal diagnostics and antifungal drug development over the past 20 years, but most of the world’s population has not yet benefited from these advances.
the lancet tv
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dr nanayakkara will be presenting his paper, recently published in the lancet respiratory medicine, at the sccm meeting in the session entitled hot topics and late-breaking science in medical journals, on tuesday feb 27, 2018.
stephen lawn memorial lecture 2018: professor liz corbett will be speaking about re-imagining hiv and tb screening on march 22, at 1715–2000 h gmt, at the john snow lecture theatre, london school of hygiene & tropical medicine, london, uk. register to attend the free lecture.